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Postdoc Research Fellow Lvl1 or Lvl2, UCD Computer Science - Computational Engineering, Computational Sciences

School/Institution:University College Dublin, Ireland, Dublin

Discipline: Computational Engineering, Computational Sciences

Employment Type:Full-time

Posted:2021-10-13

Contact Person:If you wish to apply for this position, please specify that you saw it on AKATECH.tech

The Ryan group at Systems Biology Ireland and the UCD School of Computer Science are recruiting postdoctoral fellows to work on computational approaches to understand and predict synthetic lethal interactions in cancer.
Project Description: Synthetic lethality, where one gene becomes essential in the presence of a mutation in another, has emerged as a promising approach by which we might identify new therapeutic targets for a variety of cancer associated mutations. Advances in genetic screening technologies, most notably CRISPR gene-editing, have enabled large-scale efforts to identify new synthetic lethal targets in cancer. However, testing all human gene pairs for synthetic lethality in even a single cell line is well beyond the field's current capacity. Furthermore, it has become clear that synthetic lethal interactions are highly context-specific: a combination of genetic perturbations that is lethal in one cell type or genetic background may be well tolerated in another.
The nature of this context-specificity and the factors that influence it are almost entirely unknown. However, such knowledge is critical both for identifying new synthetic lethal therapies and for anticipating resistance to such therapies.
The overall goal of this project is to understand what factors contribute to the context-specificity of synthetic lethality in cancer and to develop machine learning models capable of predicting context-specific synthetic lethality. Relevant recent papers from our lab include Lord et al, eLife (2020) and De Kegel et al, Cell Systems (2021).
This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator. The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching. In addition to the Principal Duties and Responsibilities listed below, the successful candidate will also carry out the following duties specific to this project: Collaborating with other researchers both in UCD and Externally
Equality, Diversity and Inclusion
UCD is committed to creating an inclusive environment where diversity is celebrated, and everyone is afforded equality of opportunity. To that end the university adheres to a range of equality, diversity and inclusion policies. We encourage applicants to consult those policies here https://www.ucd.ie/equality/. We welcome applications from everyone, including those who identify with any of the protected characteristics that are set out in our Equality, Diversity and Inclusion policy.
Salary range: €38,631 - €44,658 per annum for PD1 post and €45,942 per annum for PD2 post.
Appointment on the above range will be dependent on qualifications and experience
Closing date: 17:00hrs (local Irish time) on 18 October 2021
Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.
UCD offers a comprehensive Research Careers Framework in line with the Advisory Science Council Report 'Towards a Framework for Researcher Careers'. This model provides a structured and supportive Career and Skills Development system designed to ensure that Post-docs in UCD are able to plan their careers and prepare for future opportunities in academia, industry or the public sector. For more information, please click here https://www.ucd.ie/researchcareers/
Prior to application, further information (including application procedure) should be obtained from the Work at UCD website: https://www.ucd.ie/workatucd/jobs/
UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.

The Ryan group at Systems Biology Ireland and the UCD School of Computer Science are recruiting postdoctoral fellows to work on computational approaches to understand and predict synthetic lethal interactions in cancer.

 

Project Description: Synthetic lethality, where one gene becomes essential in the presence of a mutation in another, has emerged as a promising approach by which we might identify new therapeutic targets for a variety of cancer associated mutations. Advances in genetic screening technologies, most notably CRISPR gene-editing, have enabled large-scale efforts to identify new synthetic lethal targets in cancer. However, testing all human gene pairs for synthetic lethality in even a single cell line is well beyond the field's current capacity. Furthermore, it has become clear that synthetic lethal interactions are highly context-specific: a combination of genetic perturbations that is lethal in one cell type or genetic background may be well tolerated in another.

 

The nature of this context-specificity and the factors that influence it are almost entirely unknown. However, such knowledge is critical both for identifying new synthetic lethal therapies and for anticipating resistance to such therapies.

 

The overall goal of this project is to understand what factors contribute to the context-specificity of synthetic lethality in cancer and to develop machine learning models capable of predicting context-specific synthetic lethality. Relevant recent papers from our lab include Lord et al, eLife (2020) and De Kegel et al, Cell Systems (2021).

 

This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator. The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching. In addition to the Principal Duties and Responsibilities listed below, the successful candidate will also carry out the following duties specific to this project: Collaborating with other researchers both in UCD and Externally

 

Equality, Diversity and Inclusion

 

UCD is committed to creating an inclusive environment where diversity is celebrated, and everyone is afforded equality of opportunity. To that end the university adheres to a range of equality, diversity and inclusion policies. We encourage applicants to consult those policies here https://www.ucd.ie/equality/. We welcome applications from everyone, including those who identify with any of the protected characteristics that are set out in our Equality, Diversity and Inclusion policy.

 

Salary range: € 38,631 - € 44,658 per annum for PD1 post and € 45,942 per annum for PD2 post.

 

Appointment on the above range will be dependent on qualifications and experience

 

Closing date: 17: 00hrs (local Irish time) on 18 October 2021

 

Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17: 00hrs (Local Irish Time) on the specified closing date will be canceled automatically by the system. UCD are unable to accept late applications.

 

UCD offers a comprehensive Research Careers Framework in line with the Advisory Science Council Report 'Towards a Framework for Researcher Careers'. This model provides a structured and supportive Career and Skills Development system designed to ensure that Post-docs in UCD are able to plan their careers and prepare for future opportunities in academia, industry or the public sector. For more information, please click here https://www.ucd.ie/researchcareers/

 

Prior to application, further information (including application procedure) should be obtained from the Work at UCD website: https://www.ucd.ie/workatucd/jobs/

 

UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.

Contact Person: If you wish to apply for this position, please specify that you saw it on AKATECH.tech

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